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Medicina
Volume 60
Issue 7
10.3390/medicina60071025
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Open AccessBrief Report
by Viet Ha Le SciProfiles Scilit Preprints.org Google Scholar Thi Diep Khong SciProfiles Scilit Preprints.org Google Scholar Ngoc Quang Phan SciProfiles Scilit Preprints.org Google Scholar Thi Hoa Tran SciProfiles Scilit Preprints.org Google Scholar Hong Ngoc Vu SciProfiles Scilit Preprints.org Google Scholar Dong Van Quyen SciProfiles Scilit Preprints.org Google Scholar Van Thuan Hoang SciProfiles Scilit Preprints.org Google Scholar Nam Thang Nguyen SciProfiles Scilit Preprints.org Google Scholar Viet Ha Le
Thi Diep Khong
Ngoc Quang Phan
,
Thi Hoa Tran
Hong Ngoc Vu
Dong Van Quyen
,
Van Thuan Hoang
and
Nam Thang Nguyen
1
Thai Binh University of Medicine and Pharmacy, Thai Binh 410000, Vietnam
2
Biotechnology Department, Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi 11307, Vietnam
3
Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi 11307, Vietnam
*
Author to whom correspondence should be addressed.
Medicina 2024, 60(7), 1025; https://doi.org/10.3390/medicina60071025 (registeringDOI)
Submission received: 28 May 2024 / Revised: 12 June 2024 / Accepted: 18 June 2024 / Published: 21 June 2024
(This article belongs to the Section Infectious Disease)
Abstract
Background and Objectives: We aimed to investigate the carriage of colistin-resistant genes among both patients with a history of antibiotic exposure and apparently healthy adults with no recent healthcare contact. Materials and Methods: Stool swabs were collected from healthy people, and specimens were collected at the infection foci from the patients. Eleven primer/probe sets were used to perform the Multiplex Real-Time PCR assay with the QuantiNova Multiplex Probe PCR kit for screening the carriage of colistin-resistant genes (mcr-1 to mcr-10) and 16S rRNA gene as internal control. Results: In total, 86 patients and 96 healthy residents were included. Twenty two patients (25.9%) were positive with at least one colistin-resistance encoding gene. The mcr-1 gene was the most frequent (16.5%), followed by mcr-9, mcr-6, and mcr-4 genes, where the prevalence was 11.8%, 10.6%, and 9.4%, respectively. No patient was positive with mcr-3, mcr-7, and mcr-8 genes. Eight patients (9.4%) were positive with multiple colistin-encoding genes. Twenty-three healthy people (24.0%) were positive with at least one colistin-resistance encoding gene, and the mcr-10 gene was the most frequent (27.0%), followed by the mcr-1, mcr-8, and mcr-9 genes, where the prevalence was 24.3%, 21.6%, and 13.5%, respectively. No person was positive with the mcr-2 and mcr-5 genes. Conclusions: Our findings underscore the urgent need for enhanced surveillance, infection control measures, and stewardship interventions to mitigate the spread of colistin resistance in Vietnam.
Keywords: colistin-resistant encoding genes; mcr; Vietnam
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MDPI and ACS Style
Le, V.H.; Khong, T.D.; Phan, N.Q.; Tran, T.H.; Vu, H.N.; Van Quyen, D.; Hoang, V.T.; Nguyen, N.T. High Prevalence of Colistin-Resistant Encoding Genes Carriage among Patients and Healthy Residents in Vietnam. Medicina 2024, 60, 1025. https://doi.org/10.3390/medicina60071025
AMA Style
Le VH, Khong TD, Phan NQ, Tran TH, Vu HN, Van Quyen D, Hoang VT, Nguyen NT. High Prevalence of Colistin-Resistant Encoding Genes Carriage among Patients and Healthy Residents in Vietnam. Medicina. 2024; 60(7):1025. https://doi.org/10.3390/medicina60071025
Chicago/Turabian Style
Le, Viet Ha, Thi Diep Khong, Ngoc Quang Phan, Thi Hoa Tran, Hong Ngoc Vu, Dong Van Quyen, Van Thuan Hoang, and Nam Thang Nguyen. 2024. "High Prevalence of Colistin-Resistant Encoding Genes Carriage among Patients and Healthy Residents in Vietnam" Medicina 60, no. 7: 1025. https://doi.org/10.3390/medicina60071025
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MDPI and ACS Style
Le, V.H.; Khong, T.D.; Phan, N.Q.; Tran, T.H.; Vu, H.N.; Van Quyen, D.; Hoang, V.T.; Nguyen, N.T. High Prevalence of Colistin-Resistant Encoding Genes Carriage among Patients and Healthy Residents in Vietnam. Medicina 2024, 60, 1025. https://doi.org/10.3390/medicina60071025
AMA Style
Le VH, Khong TD, Phan NQ, Tran TH, Vu HN, Van Quyen D, Hoang VT, Nguyen NT. High Prevalence of Colistin-Resistant Encoding Genes Carriage among Patients and Healthy Residents in Vietnam. Medicina. 2024; 60(7):1025. https://doi.org/10.3390/medicina60071025
Chicago/Turabian Style
Le, Viet Ha, Thi Diep Khong, Ngoc Quang Phan, Thi Hoa Tran, Hong Ngoc Vu, Dong Van Quyen, Van Thuan Hoang, and Nam Thang Nguyen. 2024. "High Prevalence of Colistin-Resistant Encoding Genes Carriage among Patients and Healthy Residents in Vietnam" Medicina 60, no. 7: 1025. https://doi.org/10.3390/medicina60071025
Medicina, EISSN 1648-9144, Published by MDPI
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